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・ Zinc chloride hydroxide monohydrate
・ Zinc chromate
・ Zinc cyanide
・ Zinc D-Ala-D-Ala carboxypeptidase
・ ZINC database
・ Zinc deficiency
・ Zinc deficiency (plant disorder)
・ Zinc dithiophosphate
・ Zinc ferrite
・ Zinc finger
・ Zinc finger and BTB domain-containing protein 16
・ Zinc finger and scan domain containing 18
・ Zinc finger chimera
・ Zinc finger FYVE domain-containing protein 9
・ Zinc finger inhibitor
Zinc finger nuclease
・ Zinc finger protein 165
・ Zinc finger protein 236
・ Zinc finger protein 266
・ Zinc finger protein 516
・ Zinc finger protein 521
・ Zinc finger protein 532
・ Zinc finger protein 536
・ Zinc finger protein 608
・ Zinc finger protein 804A
・ Zinc finger protein basonuclin-2
・ Zinc finger transcription factor
・ Zinc flake coating
・ Zinc fluoride
・ Zinc gluconate


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Zinc finger nuclease : ウィキペディア英語版
Zinc finger nuclease
Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger domains can be engineered to target specific desired DNA sequences and this enables zinc-finger nucleases to target unique sequences within complex genomes. By taking advantage of endogenous DNA repair machinery, these reagents can be used to precisely alter the genomes of higher organisms.
==Domains==
A zinc finger nuclease is a site-specific endonuclease designed to bind and cleave DNA at specific positions. There are two protein domains. The first domain is the DNA binding domain, which consists of eukaryotic transcription factors and contain the zinc finger. The second domain is the nuclease domain, which consists of the FokI restriction enzyme and is responsible for the catalytic cleavage of DNA.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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